From the West Enter the Park at the West Entrance via Hwy 120 (Big Oak Flat Entrance Station) or 140 (Arch Rock Entrance Station), or from the South at the Wawona Entrance Station on Hwy 41. Get to Crane Flat. Continue east on Hwy 120 to Tuolumne Meadows. I recommend Hwy 120 or 140 over Hwy 41 due to the windiness of the mountain road. Allow at least 5 hours driving time from the Bay Area to Tuolumne Meadows.
If you are entering the park from the East at the Tioga Entrance Station: leave the town of Lee Vining on Hwy 395 and go west on Hwy 120 up incredible Lee Vining Canyon to Tuolumne Meadows. This is the recommended route for guests from Southern California or the Tahoe/Reno area.